Analysis of spironolactone polymorphs in active pharmaceutical ingredients and their effect on tablet dissolution profiles

• Main Authors: Renata Cunha de Resende (Author), Olímpia Maria Martins Santos Viana (Author), Jennifer Tavares Jacon Freitas (Author), Rudy Bonfilio (Author), André Luís Morais Ruela (Author), Magali Benjamim de Araújo (Author)
• Format: Book
• Published: Universidade de São Paulo.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT Spironolactone (SPR) is a steroidal drug administered as a potassium-sparing diuretic for high blood pressure treatment. The drug shows incomplete gastrointestinal absorption due to its poor aqueous solubility. The physicochemical properties of SPR in crystal forms I and II suggest that dif...