Discovery of a first-in-class ANXA3 degrader for the treatment of triple-negative breast cancer

• Main Authors: Yongxi Liang (Author), Delin Min (Author), Hulin Fan (Author), Kunlin Liu (Author), Juchuanli Tu (Author), Xueyan He (Author), Bingjie Liu (Author), Lu Zhou (Author), Suling Liu (Author), Xun Sun (Author)
• Format: Book
• Published: Elsevier, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triple-negative breast cancer (TNBC) is a nasty disease with extremely high malignancy and poor prognosis. Annexin A3 (ANXA3) is a potential prognosis biomarker, displaying an excellent correlation of ANXA3 overexpression with patients' poor prognosis. Silencing the expression of ANXA3 effectiv...