Identification of an Alternative Glycyrrhizin Metabolite Causing Liquorice-Induced Pseudohyperaldosteronism and the Development of ELISA System to Detect the Predictive Biomarker

• Main Authors: Kan'ichiro Ishiuchi (Author), Osamu Morinaga (Author), Tetsuhiro Yoshino (Author), Miaki Mitamura (Author), Asuka Hirasawa (Author), Yasuhito Maki (Author), Yuuna Tashita (Author), Tsubasa Kondo (Author), Kakuyou Ogawa (Author), Fangyi Lian (Author), Keiko Ogawa-Ochiai (Author), Kiyoshi Minamizawa (Author), Takao Namiki (Author), Masaru Mimura (Author), Kenji Watanabe (Author), Toshiaki Makino (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Liquorice is usually used as crude drug in traditional Japanese Kampo medicine and traditional Chinese medicine. Liquorice-containing glycyrrhizin (GL) can cause pseudohyperaldosteronism as a side effect. Previously, we identified 18β-glycyrrhetyl-3-O-sulfate (3) as a GL metabolite in Eisai hyperbil...