PBPK Model of Coproporphyrin I: Evaluation of the Impact of SLCO1B1 Genotype, Ethnicity, and Sex on its Inter‐Individual Variability

• المؤلفون الرئيسيون: Hiroyuki Takita (مؤلف), Shelby Barnett (مؤلف), Yueping Zhang (مؤلف), Karelle Ménochet (مؤلف), Hong Shen (مؤلف), Kayode Ogungbenro (مؤلف), Aleksandra Galetin (مؤلف)
• التنسيق: كتاب
• منشور في: Wiley, 2021-02-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Coproporphyrin I (CPI) is an endogenous biomarker of OATP1B activity and associated drug‐drug interactions. In this study, a minimal physiologically‐based pharmacokinetic model was developed to investigate the impact of OATP1B1 genotype (c.521T>C), ethnicity, and sex on CPI pharmacokinetics and i...