PBPK Model of Coproporphyrin I: Evaluation of the Impact of SLCO1B1 Genotype, Ethnicity, and Sex on its Inter‐Individual Variability

• Asıl Yazarlar: Hiroyuki Takita (Yazar), Shelby Barnett (Yazar), Yueping Zhang (Yazar), Karelle Ménochet (Yazar), Hong Shen (Yazar), Kayode Ogungbenro (Yazar), Aleksandra Galetin (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2021-02-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Coproporphyrin I (CPI) is an endogenous biomarker of OATP1B activity and associated drug‐drug interactions. In this study, a minimal physiologically‐based pharmacokinetic model was developed to investigate the impact of OATP1B1 genotype (c.521T>C), ethnicity, and sex on CPI pharmacokinetics and i...