COX-2 is required to mediate crosstalk of ROS-dependent activation of MAPK/NF-κB signaling with pro-inflammatory response and defense-related NO enhancement during challenge of macrophage-like cell line with Giardia duodenalis.

• Main Authors: Yudan Zhao (Author), Yongwu Yang (Author), Min Liu (Author), Xuening Qin (Author), Xiran Yu (Author), Huimin Zhao (Author), Xiaoyun Li (Author), Wei Li (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Giardia duodenalis, the causative agent of giardiasis, is among the most important causes of waterborne diarrheal diseases around the world. Giardia infection may persist over extended periods with intestinal inflammation, although minimal. Cyclooxygenase (COX)-2 is well known as an important induce...