Discovery of pulmonary fibrosis inhibitor targeting TGF-β RI in Polygonum cuspidatum by high resolution mass spectrometry with in silico strategy

• المؤلفون الرئيسيون: Huarong Xu (مؤلف), Jiameng Qu (مؤلف), Jian Wang (مؤلف), Kefei Han (مؤلف), Qing Li (مؤلف), Wenchuan Bi (مؤلف), Ran Liu (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2022-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Pulmonary fibrosis (PF) is an irreversible lung disease that is characterized by excessive scar tissue with a poor median survival rate of 2-3 years. The inhibition of transforming growth factor-β receptor type-I (TGF-β RI) by an appropriate drug may provide a promising strategy for the treatment of...