Synthesis, Screening and Characterization of Novel Potent Arp2/3 Inhibitory Compounds Analogous to CK-666

• Hoofdauteurs: Artem I. Fokin (Auteur), Roman N. Chuprov-Netochin (Auteur), Alexander S. Malyshev (Auteur), Stéphane Romero (Auteur), Marina N. Semenova (Auteur), Leonid D. Konyushkin (Auteur), Sergey V. Leonov (Auteur), Victor V. Semenov (Auteur), Alexis M. Gautreau (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Branched actin networks polymerized by the Actin-related protein 2 and 3 (Arp2/3) complex play key roles in force generation and membrane remodeling. These networks are particularly important for cell migration, where they drive membrane protrusions of lamellipodia. Several Arp2/3 inhibitory compoun...