Allogenic Fc Domain-Facilitated Uptake of IgG in Nasal Lamina Propria: Friend or Foe for Intranasal CNS Delivery?

Allogenic Fc Domain-Facilitated Uptake of IgG in Nasal Lamina Propria: Friend or Foe for Intranasal CNS Delivery?

Background: The use of therapeutic antibodies for the treatment of neurological diseases is of increasing interest. Nose-to-brain drug delivery is one strategy to bypass the blood brain barrier. The neonatal Fc receptor (FcRn) plays an important role in transepithelial transcytosis of immunoglobulin...

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Main Authors: Simone Ladel (Author), Johannes Flamm (Author), Arghavan Soleimani Zadeh (Author), Dorothea Filzwieser (Author), Julia-Christina Walter (Author), Patrick Schlossbauer (Author), Ralf Kinscherf (Author), Katharina Lischka (Author), Harald Luksch (Author), Katharina Schindowski (Author)
Format: Book
Published: MDPI AG, 2018-07-01T00:00:00Z.
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3rd Floor Main Library

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