Design, synthesis and biological evaluation of novel diosgenin-benzoic acid mustard hybrids with potential anti-proliferative activities in human hepatoma HepG2 cells

• Main Authors: Jinling Zhang (Author), Wenbao Wang (Author), Yanzhao Tian (Author), Liwei Ma (Author), Lin Zhou (Author), Hao Sun (Author), Yukun Ma (Author), Huiling Hou (Author), Xiaoli Wang (Author), Jin Ye (Author), Xiaobo Wang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To discover new lead compounds with anti-tumour activities, in the present study, natural diosgenin was hybridised with the reported benzoic acid mustard pharmacophore. The in vitro cytotoxicity of the resulting newly synthesised hybrids (8-10, 14a-14f, and 15a-15f) was then evaluated in three tumou...