Anti-Inflammatory Activity of a Cyclic Tetrapeptide in Mouse and Human Experimental Models

• Main Authors: Michał Zimecki (Author), Jolanta Artym (Author), Wojciech Kałas (Author), Leon Strządała (Author), Katarzyna Kaleta-Kuratewicz (Author), Jan Kuryszko (Author), Andrzej Kaszuba (Author), Krzysztof Kaczmarek (Author), Janusz Zabrocki (Author)
• Format: Book
• Published: MDPI AG, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A cyclic tetrapeptide Pro-Pro-Pheβ³ho-Phe (4B8M) was tested for immunosuppressive activity and potential therapeutic utility in several in vitro and in vivo mouse and human models. The tetrapeptide was less toxic for mouse splenocytes in comparison to cyclosporine A (CsA) and...