Blockage of Eosinopoiesis by IL-17A Is Prevented by Cytokine and Lipid Mediators of Allergic Inflammation

• Main Authors: Pedro Xavier-Elsas (Author), Bianca de Luca (Author), Túlio Queto (Author), Bruno Marques Vieira (Author), Daniela Masid- (Author), Elizabeth Chen Dahab (Author), José Carlos Alves Filho (Author), Fernando Q. Cunha (Author), Maria Ignez C. Gaspar-Elsas (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Interleukin- (IL-) 17A, a pleiotropic mediator of inflammation and autoimmunity, potently stimulates bone-marrow neutrophil production. To explore IL-17A effects on eosinopoiesis, we cultured bone-marrow from wild-type mice, or mutants lacking inducible nitric oxide synthase (iNOS−/−), CD95 (lpr), I...