Discovery of Novel Allosteric SHP2 Inhibitor Using Pharmacophore-Based Virtual Screening, Molecular Docking, Molecular Dynamics Simulation, and Principal Component Analysis
SHP2 belongs to a cytoplasmic non-receptor protein tyrosine phosphatase class. It plays a critical role in the development of various cancers, such as gastric cancer, leukemia, and breast cancer. Thus, SHP2 has gained the interest of researchers as a potential target for inhibiting tumor cell prolif...
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| Main Authors: | , , , |
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| Format: | Book |
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MDPI AG,
2024-07-01T00:00:00Z.
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| Call Number: |
A1234.567 |
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| Copy 1 | Available |