Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines

• Main Authors: Olga Cruz-López (Author), Matilde Ner (Author), Francho Nerín-Fonz (Author), Yaiza Jiménez-Martínez (Author), David Araripe (Author), Juan A. Marchal (Author), Houria Boulaiz (Author), Hugo Gutiérrez- (Author), Joaquín M. Campos (Author), Ana Conejo-García (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of 11 new substituted 1,5-dihydro-4,1-benzoxazepine derivatives was synthesised to study the influence of the methyl group in the 1-(benzenesulphonyl) moiety, the replacement of the purine by the benzotriazole bioisosteric analogue, and the introduction of a bulky substituent at position 6...