New Imadazopyrazines with CDK9 Inhibitory Activity as Anticancer and Antiviral: Synthesis, In Silico, and In Vitro Evaluation Approaches

New Imadazopyrazines with CDK9 Inhibitory Activity as Anticancer and Antiviral: Synthesis, In Silico, and In Vitro Evaluation Approaches

This study describes the synthesis and biological activity of new imadazopyrazines as first-in-class CDK9 inhibitors. The inhibition of CDK9 is a well-established therapeutic target in cancer therapy. The new compounds were assessed using an in vitro kinase assay against CDK9. In this assay, compoun...

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Main Authors: Aisha A. Alsfouk (Author), Hanan M. Alshibl (Author), Najla A. Altwaijry (Author), Ashwag Alanazi (Author), Omkulthom AlKamaly (Author), Ahlam Sultan (Author), Bshra A. Alsfouk (Author)
Format: Book
Published: MDPI AG, 2023-07-01T00:00:00Z.
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