Fibroblast growth factor 21 has no direct role in regulating fertility in female mice

• Main Authors: Garima Singhal (Author), Nicholas Douris (Author), Alan J. Fish (Author), Xinyao Zhang (Author), Andrew C. Adams (Author), Jeffrey S. Flier (Author), Pavlos Pissios (Author), Eleftheria Maratos-Flier (Author)
• Format: Book
• Published: Elsevier, 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Reproduction is an energetically expensive process. Insufficient calorie reserves, signaled to the brain through peripheral signals such as leptin, suppress fertility. Recently, fibroblast growth factor 21 (FGF21) was implicated as a signal from the liver to the hypothalamus that directly...