PICK1 Deficiency Induces Autophagy Dysfunction via Lysosomal Impairment and Amplifies Sepsis-Induced Acute Lung Injury

• Main Authors: Yunchang Mo (Author), Yingying Lou (Author), Anqi Zhang (Author), Jingjing Zhang (Author), Congying Zhu (Author), Bo Zheng (Author), Dan Li (Author), Mingyuan Zhang (Author), Wenjun Jin (Author), Lei Zhang (Author), Junlu Wang (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sepsis is a systemic inflammatory reaction caused by infection. Multiple organ failure ultimately leads to high morbidity and mortality. Unfortunately, therapies against these responses have been unsuccessful due to the insufficient underlying pathophysiological evidence. Protein interacting with C-...