Suppression of mICAT in Mouse Small Intestinal Myocytes by General Anaesthetic Ketamine and its Recovery by TRPC4 Agonist (-)-englerin A

• Egile Nagusiak: Mariia I. Melnyk (Egilea), Dariia O. Dryn (Egilea), Lina T. Al Kury (Egilea), Dmytro O. Dziuba (Egilea), Alexander V. Zholos (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

A better understanding of the negative impact of general anesthetics on gastrointestinal motility requires thorough knowledge of their molecular targets. In this respect the muscarinic cationic current (mICAT carried mainly via TRPC4 channels) that initiates cholinergic excitation-contraction coupli...