Ezetimibe, Niemann-Pick C1 like 1 inhibitor, modulates hepatic phospholipid metabolism to alleviate fat accumulation

• Main Authors: Hyekyung Yang (Author), Dong Ho Suh (Author), Eun Sung Jung (Author), Yoonjin Lee (Author), Kwang-Hyeon Liu (Author), In-Gu Do (Author), Choong Hwan Lee (Author), Cheol-Young Park (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundEzetimibe, which lowers cholesterol by blocking the intestinal cholesterol transporter Niemann-Pick C1 like 1, is reported to reduce hepatic steatosis in humans and animals. Here, we demonstrate the changes in hepatic metabolites and lipids and explain the underlying mechanism of ezetimibe...