Post-Translational Modification Analysis of VDAC1 in ALS-SOD1 Model Cells Reveals Specific Asparagine and Glutamine Deamidation

• Main Authors: Maria Gaetana Giovanna Pittalà (Author), Simona Reina (Author), Salvatore Antonio Maria Cubisino (Author), Annamaria Cucina (Author), Beatrice Formicola (Author), Vincenzo Cunsolo (Author), Salvatore Foti (Author), Rosaria Saletti (Author), Angela Messina (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondria from affected tissues of amyotrophic lateral sclerosis (ALS) patients show morphological and biochemical abnormalities. Mitochondrial dysfunction causes oxidative damage and the accumulation of ROS, and represents one of the major triggers of selective death of motor neurons in ALS. We...