Deliberate attenuation of chikungunya virus by adaptation to heparan sulfate-dependent infectivity: a model for rational arboviral vaccine design.

• Main Authors: Christina L Gardner (Author), Jozef Hritz (Author), Chengqun Sun (Author), Dana L Vanlandingham (Author), Timothy Y Song (Author), Elodie Ghedin (Author), Stephen Higgs (Author), William B Klimstra (Author), Kate D Ryman (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mosquito-borne chikungunya virus (CHIKV) is a positive-sense, single-stranded RNA virus from the genus Alphavirus, family Togaviridae, which causes fever, rash and severe persistent polyarthralgia in humans. Since there are currently no FDA licensed vaccines or antiviral therapies for CHIKV, the dev...