Cutaneous Side Effects of BRAF Inhibitors in Advanced Melanoma: Review of the Literature
The incidence of melanoma has recently been increasing. BRAF mutations have been found in 40-60% of melanomas. The increased activity of BRAF V600E leads to the activation of downstream signaling through the mitogen-activated protein kinase (MAPK) pathway, which plays a key role as a regulator of ce...
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Hindawi Limited,
2016-01-01T00:00:00Z.
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