Effects of Low Concentrations of Rotenone Upon Mitohormesis in SH-SY5Y Cells

• Main Authors: Xiong Yuyun (Author), Qian Jinjun (Author), Xu Minfang (Author), Qiu Jing (Author), Xia Juan (Author), Ma Rui (Author), Zhu Li (Author), Gao Jing (Author)
• Format: Book
• Published: SAGE Publishing, 2013-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mitochondrial toxin rotenone exerts cytotoxicity via overproduction of reactive oxygen species (ROS) and depolarization of the mitochondrial membrane. We investigated the effects of rotenone (12.5, 25, 50, 100 nmol/L) on mitochondrial biogenesis and the potential roles of ROS production in SH-SY...