Epitope Capsid-Incorporation: New Effective Approach for Vaccine Development for Chagas Disease

• Main Authors: Qiana L. Matthews (Author), Anitra L. Farrow (Author), Girish Rachakonda (Author), Linlin Gu (Author), Pius Nde (Author), Alexandre Krendelchtchikov (Author), Siddarth Pratap (Author), Shruti S. Sakhare (Author), Steffanie Sabbaj (Author), Maria F. Lima (Author), Fernando Villalta (Author)
• Format: Book
• Published: Case Western Reserve University, 2016-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Previously we reported that a hexon-modified adenovirus (Ad) vector containing the invasive neutralizing epitope of Trypanosoma cruzi (T. cruzi) trypomastigote gp83 (Ad5-gp83) provided immunoprotection against T. cruzi infection. The purpose of this work was to design an improved vaccine...