Bispecific antibody target pair discovery by high-throughput phenotypic screening using in vitro combinatorial Fab libraries

• Main Authors: Pallavi Bhatta (Author), Kevin D. Whale (Author), Amy K. Sawtell (Author), Clare L. Thompson (Author), Stephen E. Rapecki (Author), David A. Cook (Author), Breda M. Twomey (Author), Milena Mennecozzi (Author), Laura E. Starkie (Author), Emily M. C. Barry (Author), Shirley J. Peters (Author), Ahmad M. Kamal (Author), Helene M. Finney (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bispecific antibodies can uniquely influence cellular responses, but selecting target combinations for optimal functional activity remains challenging. Here we describe a high-throughput, combinatorial, phenotypic screening approach using a new bispecific antibody target discovery format, allowing s...