Determination of atractylon in rat plasma by a GCâMS method and its application to a pharmacokinetic study

• Main Authors: Han Yan (Author), Yuanyuan Sun (Author), Yuying Ma (Author), Bin Ji (Author), Xiaohong Hou (Author), Zhiguo Yu (Author), Yunli Zhao (Author)
• Format: Book
• Published: Elsevier, 2015-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A sensitive and selective method based on gas chromatography hyphenated to mass spectrometry (GCâMS) was developed and validated for the determination of atractylon in rat plasma. Plasma samples were processed by liquidâliquid extraction with ethyl acetate-n-hexane (1:1, v/v) using acetophenone as a...