High-capacity adenovector delivery of forced CRISPR-Cas9 heterodimers fosters precise chromosomal deletions in human cells

Genome editing based on dual CRISPR-Cas9 complexes (multiplexes) permits removing specific genomic sequences in living cells leveraging research on functional genomics and genetic therapies. Delivering the required large and multicomponent reagents in a synchronous and stoichiometric manner remains,...

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Main Authors: Francesca Tasca (Author), Marcella Brescia (Author), Jin Liu (Author), Josephine M. Janssen (Author), Kamel Mamchaoui (Author), Manuel A.F.V. Gonçalves (Author)
Format: Book
Published: Elsevier, 2023-03-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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