Antihyperglycaemic and haematological effects of ethanol extract of Salacia lehmbachii leaf in alloxan-induced diabetic Wistar rats

• Main Authors: Godwin Christian Akuodor (Author), Pius Monday Udia (Author), Sylvester Chika Ohadoma (Author), Ifeanyi M. Obi (Author), Anthony Uchenna Megwas (Author), Jane Ugochi Chilaka (Author), Kingsley Chimsorom Chilaka (Author), Francis Vincent Udoh (Author)
• Format: Book
• Published: Shahrekord University of Medical Sciences, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Introduction: Salacia lehmbachii is used traditionally for the treatment of diabetes mellitus. This study investigated the hypoglycaemic potentials of ethanol leaf extract of S. lehmbachii and its effects on alloxan-induced diabetic rats' haematological parameters. Methods: A total of 36 male Wistar rats including normal, diabetic untreated, and diabetic treated ones were used in this study. Diabetes was induced by a single intraperitoneal injection of 150 mg/kg of alloxan. When confirmed diabetes, the rats were orally administered 100 mg/kg, 200 mg/kg, and 400 mg/kg daily of the leaf extract for 21 days. The blood glucose levels and haematological parameters were determined in diabetic treated rats compared with the controls. Results: The ethanol leaf extract of S. lehmbachii significantly reduced the blood glucose levels of alloxan-induced diabetic rats when compared with the diabetic control (P < 0.01). The extract also significantly (P < 0.01) improved the haematological parameters of treated rats at three doses employed. Conclusion: It can be concluded that the ethanol leaf extract of S. lehmbachii possesses antihyperglycaemic properties and could be considered a potential candidate for the development of new drugs in the treatment of anaemic conditions.

Item Description

2345-5004
10.34172/jhp.2021.46