Cytotoxic and Infection-Controlled Investigations of Novel Dihydropyridine Hybrids: An Efficient Synthesis and Molecular-Docking Studies
A sequence of novel 1,4-dihydropyridines (DHP) and their hybrids was developed using a multicomponent strategy under environmentally benign conditions. In addition, computational studies were performed, and the ligand-protein interactions calculated in different bacteria and two fungal strains. Para...
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| Main Authors: | , , , , |
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| Format: | Book |
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MDPI AG,
2023-08-01T00:00:00Z.
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| Summary: | A sequence of novel 1,4-dihydropyridines (DHP) and their hybrids was developed using a multicomponent strategy under environmentally benign conditions. In addition, computational studies were performed, and the ligand-protein interactions calculated in different bacteria and two fungal strains. Para-hydroxy-linked DHP (<b>5f</b>) showed the best binding energies of 3.591, 3.916, 8.499 and 6.895 kcal/mol against various pathogens used and other substances received a good docking score. The pathogen resistance potential of the synthesized targets against four bacteria and two fungi showed that whole DHP substances exhibit different levels of resistance to each microorganism. Gram-positive bacteria, which are highly sensitive to all molecules, and the MTCC-1884-encoded fungus strongly rejected the studied compounds compared to comparator drugs. In particular, the <b>5f</b> candidate showed remarkable antimicrobial activity, followed by the substances <b>5a</b>, <b>5b</b>, <b>5j</b>, <b>5k</b> and <b>5l</b>. Furthermore, MIC and MBC/MFC properties showed that <b>5f</b> had a minimum bacterial concentration of 12.5 μg/mL against <i>E. coli</i> and against two fungal pathogens, with its killing activity being effective even at low concentrations. On the other hand, whole motifs were tested for their cytotoxic activity, revealing that the methoxy and hydroxy-linked compounds (<b>5h</b>) showed greater cytotoxic potency, followed by the two hydroxy linked compounds (<b>5d</b> and <b>5f</b>). Overall, this synthetic approach used represents a prototype for future nature-favored synthesis methods and these biological results serve as a guide for future therapeutic drug research. However, the computer results play an important role in the further development of biological experiments. |
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| Item Description: | 10.3390/ph16081159 1424-8247 |