THE TRAFFICKING OF THE WATER CHANNEL AQUAPORIN-2 IN RENAL PRINCIPAL CELLS - A POTENTIAL TARGET FOR PHARMACOLOGICAL INTERVENTION IN CARDIOVASCULAR DISEASES

• Main Authors: Tanja eVukicevic (Author), Maike eSchulz (Author), Dörte eFaust (Author), Enno eKlussmann (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Arginine-vasopressin (AVP) stimulates the redistribution of water channels, aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane of renal collecting duct principal cells. By this AVP directs 10 % of the water reabsorption from the 170 L of primary urine that the human kidneys prod...