CX3CL1-CX3CR1 axis protects retinal ganglion cells by inhibiting microglia activation in a distal optic nerve trauma model

• Main Authors: Huan Yu (Author), Bingqiao Shen (Author), Ruiqi Han (Author), Yang Zhang (Author), Shushu Xu (Author), Yumeng Zhang (Author), Yanzhi Guo (Author), Ping Huang (Author), Shouyue Huang (Author), Yisheng Zhong (Author)
• Format: Book
• Published: BMC, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The chemokine CX3CL1 has been reported to play an important role in optic nerve protection, but the underlying mechanism is still unclear. CX3CR1, the only receptor of CX3CL1, is specifically expressed on retinal microglia, whose activation plays a role in the pathological proces...