lncRNA TRMP-S directs dual mechanisms to regulate p27-mediated cellular senescence

• Main Authors: Tian Shuai (Author), Muhammad Riaz Khan (Author), Xu Dong Zhang (Author), Jingmin Li (Author), Rick Francis Thorne (Author), Mian Wu (Author), Fengmin Shao (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Long noncoding RNAs (lncRNAs) undergo extensive alternative splicing, but little is known about isoform functions. A prior investigation of lncRNA RP11-369C8.1 reported that its splice variant TRMP suppressed p27 translation through PTBP1. Here we characterize a second major splice variant, TRMP-S (...