lncRNA TRMP-S directs dual mechanisms to regulate p27-mediated cellular senescence

• Principais autores: Tian Shuai (Autor), Muhammad Riaz Khan (Autor), Xu Dong Zhang (Autor), Jingmin Li (Autor), Rick Francis Thorne (Autor), Mian Wu (Autor), Fengmin Shao (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2021-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Long noncoding RNAs (lncRNAs) undergo extensive alternative splicing, but little is known about isoform functions. A prior investigation of lncRNA RP11-369C8.1 reported that its splice variant TRMP suppressed p27 translation through PTBP1. Here we characterize a second major splice variant, TRMP-S (...