Effects of Fibrotic Tissue on Liver-targeted Hydrodynamic Gene Delivery

• Main Authors: Yuji Kobayashi (Author), Kenya Kamimura (Author), Hiroyuki Abe (Author), Takeshi Yokoo (Author), Kohei Ogawa (Author), Yoko Shinagawa-Kobayashi (Author), Ryo Goto (Author), Ryosuke Inoue (Author), Masato Ohtsuka (Author), Hiromi Miura (Author), Tsutomu Kanefuji (Author), Takeshi Suda (Author), Masanori Tsuchida (Author), Yutaka Aoyagi (Author), Guisheng Zhang (Author), Dexi Liu (Author), Shuji Terai (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hydrodynamic gene delivery is a common method for gene transfer to the liver of small animals, and its clinical applicability in large animals has been demonstrated. Previous studies focused on functional analyses of therapeutic genes in animals with normal livers and little, however, is known regar...