Adipocytes fail to maintain cellular identity during obesity due to reduced PPARγ activity and elevated TGFβ-SMAD signaling

• প্রধান লেখক: Hyun Cheol Roh (লেখক), Manju Kumari (লেখক), Solaema Taleb (লেখক), Danielle Tenen (লেখক), Christopher Jacobs (লেখক), Anna Lyubetskaya (লেখক), Linus T.-Y. Tsai (লেখক), Evan D. Rosen (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2020-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Objective: Obesity due to overnutrition causes adipose tissue dysfunction, which is a critical pathological step on the road to type 2 diabetes (T2D) and other metabolic disorders. In this study, we conducted an unbiased investigation into the fundamental molecular mechanisms by which adipocytes tra...