Adipocytes fail to maintain cellular identity during obesity due to reduced PPARγ activity and elevated TGFβ-SMAD signaling

• Main Authors: Hyun Cheol Roh (Author), Manju Kumari (Author), Solaema Taleb (Author), Danielle Tenen (Author), Christopher Jacobs (Author), Anna Lyubetskaya (Author), Linus T.-Y. Tsai (Author), Evan D. Rosen (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Obesity due to overnutrition causes adipose tissue dysfunction, which is a critical pathological step on the road to type 2 diabetes (T2D) and other metabolic disorders. In this study, we conducted an unbiased investigation into the fundamental molecular mechanisms by which adipocytes tra...