Reduction of senescent fibro‐adipogenic progenitors in progeria‐aged muscle by senolytics rescues the function of muscle stem cells

• Main Authors: Lei Liu (Author), Xianlin Yue (Author), Zewei Sun (Author), William S. Hambright (Author), Jianming Wei (Author), Ying Li (Author), Polina Matre (Author), Yan Cui (Author), Zhihui Wang (Author), George Rodney (Author), Johnny Huard (Author), Paul D. Robbins (Author), Xiaodong Mu (Author)
• Format: Book
• Published: Wiley, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Fibro‐adipogenic progenitors (FAPs) in the muscles have been found to interact closely with muscle progenitor/stem cells (MPCs) and facilitate muscle regeneration at normal conditions. However, it is not clear how FAPs may interact with MPCs in aged muscles. Senolytics have been...