The lysosome as a novel therapeutic target of EGFR-mediated tumor inflammation

• Main Authors: Woo Jung Sung (Author), Dohyang Kim (Author), Anlin Zhu (Author), Namki Cho (Author), Hee Min Yoo (Author), Ji Heon Noh (Author), Kyoung Mi Kim (Author), Hyun-Su Lee (Author), Jaewoo Hong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

EGFR-mediated tumors have been targeted to overcome several different malignant cancers. EGFR overexpression and mutations are directly related to the malignancy, which makes the therapy more complicated. One reason for the malignancy is the induction of AP1 followed by inflammation via IL-6 secreti...