Metformin Regulates Alveolar Macrophage Polarization to Protect Against Acute Lung Injury in Rats Caused by Paraquat Poisoning

• Main Authors: Ding Yuan (Author), Yi Li (Author), Linlin Hou (Author), Fang Yang (Author), Cuicui Meng (Author), Yanwu Yu (Author), Changhua Sun (Author), Guoyu Duan (Author), Zhigao Xu (Author), Guiying Zhu (Author), Jianjun Guo (Author), Leilei Zhang (Author), Gaiqin Yan (Author), Jihong Chen (Author), Yanan Yang (Author), Yan Zhang (Author), Yanxia Gao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study explored the role of metformin (MET) in regulating the polarization of alveolar macrophages to protect against acute lung injury (ALI) in rats caused by paraquat (PQ) poisoning. The in vivo studies showed that the 35 mg/kg dose of MET increased the survival rate of rats, alleviated pathol...