The Tarantula Venom Peptide Eo1a Binds to the Domain II S3-S4 Extracellular Loop of Voltage-Gated Sodium Channel NaV1.8 to Enhance Activation

• Main Authors: Jennifer R. Deuis (Author), Lotten Ragnarsson (Author), Samuel D. Robinson (Author), Zoltan Dekan (Author), Lerena Chan (Author), Ai-Hua Jin (Author), Poanna Tran (Author), Kirsten L. McMahon (Author), Shengnan Li (Author), John N. Wood (Author), James J. Cox (Author), Glenn F. King (Author), Volker Herzig (Author), Irina Vetter (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Venoms from cone snails and arachnids are a rich source of peptide modulators of voltage-gated sodium (NaV) channels, however relatively few venom-derived peptides with activity at the mammalian NaV1.8 subtype have been isolated. Here, we describe the discovery and functional characterisation of β-t...