Pharmacological Profiles of the Novel Analgesic M58996 in Rat Models of Persistent and Neuropathic Pain

• Main Authors: Yasushige Akada (Author), Reiko Mori (Author), Kazuyuki Matsuura (Author), Kazuhiro Suzuki (Author), Kazuo Kato (Author), Masatsugu Kamiya (Author), Hiroyasu Naba (Author), Misao Kurokawa (Author), Takuo Ogihara (Author), Yutaka Kato (Author), Fumiaki Yamasaki (Author), Ichiro Yamamoto (Author)
• Format: Book
• Published: Elsevier, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the effects of 4-(N-{1-[2-(4-cyanophenyl)ethyl]-4-hydroxypiperidin-4-ylmethyl}-N-methylamino)benzoic acid monohydrochloride (M58996), a novel analgesic, on persistent and neuropathic pain in rats. In the formalin test, oral M58996 (0.3 - 10 mg/kg) reduced nociceptive behaviors only i...