Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls

• Main Authors: Hartmut Jaeschke (Author), Olamide B. Adelusi (Author), Jephte Y. Akakpo (Author), Nga T. Nguyen (Author), Giselle Sanchez-Guerrero (Author), David S. Umbaugh (Author), Wen-Xing Ding (Author), Anup Ramachandran (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at therapeutic doses but can cause severe liver injury and even liver failure after overdoses. The mouse model of APAP hepatotoxicity recapitulates closely the human pathophysiology. As a result, this clinically rele...