Cajanin Stilbene Acid Inhibited Vancomycin-Resistant Enterococcus by Inhibiting Phosphotransferase System
Antimicrobial resistance has become a serious threat to human and animal health, and vancomycin-resistant Enterococcus has become an important nosocomial infection pathogen, causing thousands of deaths each year. In this study, after screening a variety of natural products, we found that cajanin sti...
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Frontiers Media S.A.,
2020-04-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_bd6f60abd5064a3aa55ebfac361a09a5 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Shengnan Tan |e author |
| 700 | 1 | 0 | |a Shengnan Tan |e author |
| 700 | 1 | 0 | |a Xin Hua |e author |
| 700 | 1 | 0 | |a Xin Hua |e author |
| 700 | 1 | 0 | |a Zheyong Xue |e author |
| 700 | 1 | 0 | |a Zheyong Xue |e author |
| 700 | 1 | 0 | |a Zheyong Xue |e author |
| 700 | 1 | 0 | |a Jianzhang Ma |e author |
| 245 | 0 | 0 | |a Cajanin Stilbene Acid Inhibited Vancomycin-Resistant Enterococcus by Inhibiting Phosphotransferase System |
| 260 | |b Frontiers Media S.A., |c 2020-04-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2020.00473 | ||
| 520 | |a Antimicrobial resistance has become a serious threat to human and animal health, and vancomycin-resistant Enterococcus has become an important nosocomial infection pathogen, causing thousands of deaths each year. In this study, after screening a variety of natural products, we found that cajanin stilbene acid (CSA) had significant inhibitory effect on sensitive and vancomycin-resistant Enterococcus (VRE) in vitro. And we also confirmed that CSA had significant anti-VRE infection ability in vivo. Subsequently, we studied the antibacterial mechanism of CSA through proteomics experiments, and the results showed that CSA killed Enterococcus by inhibiting the phosphotransferase system of Enterococcus, thus hinders the normal growth and metabolic functions of bacteria. The results of this study provided evidence for the in-depth study on the mechanism of the antibacterial action of CSA and also provided a candidate for the development of anti-VRE drugs. | ||
| 546 | |a EN | ||
| 690 | |a vancomycin-resistant Enterococcus (VRE) | ||
| 690 | |a phosphotransferase system (PTS) | ||
| 690 | |a cajanin stilbene acid (CSA) | ||
| 690 | |a proteomics | ||
| 690 | |a inhibition mechanism | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 11 (2020) | |
| 787 | 0 | |n https://www.frontiersin.org/article/10.3389/fphar.2020.00473/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/bd6f60abd5064a3aa55ebfac361a09a5 |z Connect to this object online. |