A robust luminescent assay for screening alkyladenine DNA glycosylase inhibitors to overcome DNA repair and temozolomide drug resistance

• Główni autorzy: Ying-Qi Song (Autor), Guo-Dong Li (Autor), Dou Niu (Autor), Feng Chen (Autor), Shaozhen Jing (Autor), Vincent Kam Wai Wong (Autor), Wanhe Wang (Autor), Chung-Hang Leung (Autor)
• Format: Książka
• Wydane: Elsevier, 2023-05-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Temozolomide (TMZ) is an anticancer agent used to treat glioblastoma, typically following radiation therapy and/or surgical resection. However, despite its effectiveness, at least 50% of patients do not respond to TMZ, which is associated with repair and/or tolerance of TMZ-induced DNA lesions. Stud...