A robust luminescent assay for screening alkyladenine DNA glycosylase inhibitors to overcome DNA repair and temozolomide drug resistance

• Main Authors: Ying-Qi Song (Author), Guo-Dong Li (Author), Dou Niu (Author), Feng Chen (Author), Shaozhen Jing (Author), Vincent Kam Wai Wong (Author), Wanhe Wang (Author), Chung-Hang Leung (Author)
• Format: Book
• Published: Elsevier, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Temozolomide (TMZ) is an anticancer agent used to treat glioblastoma, typically following radiation therapy and/or surgical resection. However, despite its effectiveness, at least 50% of patients do not respond to TMZ, which is associated with repair and/or tolerance of TMZ-induced DNA lesions. Stud...