Evaluation of the usefulness of plasma 4β‐hydroxycholesterol concentration normalized by 4α‐hydroxycholesterol for accurate CYP3A phenotyping

• Κύριοι συγγραφείς: Ayako Oda (Συγγραφέας), Yosuke Suzuki (Συγγραφέας), Haruki Sato (Συγγραφέας), Teruhide Koyama (Συγγραφέας), Masahiro Nakatochi (Συγγραφέας), Yukihide Momozawa (Συγγραφέας), Ryota Tanaka (Συγγραφέας), Hiroyuki Ono (Συγγραφέας), Ryosuke Tatsuta (Συγγραφέας), Tadasuke Ando (Συγγραφέας), Toshitaka Shin (Συγγραφέας), Kenji Wakai (Συγγραφέας), Keitaro Matsuo (Συγγραφέας), Hiroki Itoh (Συγγραφέας), Keiko Ohno (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Wiley, 2024-03-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Abstract Plasma 4β‐hydroxycholesterol (OHC) has drawn attention as an endogenous substrate indicating CYP3A activity. Plasma 4β‐OHC is produced by hydroxylation by CYP3A4 and CYP3A5 and by cholesterol autoxidation. Plasma 4α‐OHC is produced by cholesterol autoxidation and not affected by CYP3A activ...