Evaluation of the usefulness of plasma 4β‐hydroxycholesterol concentration normalized by 4α‐hydroxycholesterol for accurate CYP3A phenotyping

• Main Authors: Ayako Oda (Author), Yosuke Suzuki (Author), Haruki Sato (Author), Teruhide Koyama (Author), Masahiro Nakatochi (Author), Yukihide Momozawa (Author), Ryota Tanaka (Author), Hiroyuki Ono (Author), Ryosuke Tatsuta (Author), Tadasuke Ando (Author), Toshitaka Shin (Author), Kenji Wakai (Author), Keitaro Matsuo (Author), Hiroki Itoh (Author), Keiko Ohno (Author)
• Format: Book
• Published: Wiley, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Plasma 4β‐hydroxycholesterol (OHC) has drawn attention as an endogenous substrate indicating CYP3A activity. Plasma 4β‐OHC is produced by hydroxylation by CYP3A4 and CYP3A5 and by cholesterol autoxidation. Plasma 4α‐OHC is produced by cholesterol autoxidation and not affected by CYP3A activ...