Annexin A2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and Ebola virus infections.

• Main Authors: Zhengchen Su (Author), Qing Chang (Author), Aleksandra Drelich (Author), Thomas Shelite (Author), Barbara Judy (Author), Yakun Liu (Author), Jie Xiao (Author), Changchen Zhou (Author), Xi He (Author), Yang Jin (Author), Tais Saito (Author), Shaojun Tang (Author), Lynn Soong (Author), Maki Wakamiya (Author), Xiang Fang (Author), Alexander Bukreyev (Author), Thomas Ksiazek (Author), William K Russell (Author), Bin Gong (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intracerebral microhemorrhages (CMHs) are small foci of hemorrhages in the cerebrum. Acute infections induced by some intracellular pathogens, including rickettsia, can result in CMHs. Annexin a2 (ANXA2) has been documented to play a functional role during intracellular bacterial adhesion. Here we r...