SHP2 inhibitor PHPS1 ameliorates acute kidney injury by Erk1/2-STAT3 signaling in a combined murine hemorrhage followed by septic challenge model

• Main Authors: Jihong Jiang (Author), Baoji Hu (Author), Chun-Shiang Chung (Author), Yaping Chen (Author), Yunhe Zhang (Author), Elizabeth W. Tindal (Author), Jinbao Li (Author), Alfred Ayala (Author)
• Format: Book
• Published: BMC, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Hypovolemic shock and septic challenge are two major causes of acute kidney injury (AKI) in the clinic setting. Src homology 2 domain-containing phosphatase 2 (SHP2) is one of the major protein phosphatase tyrosine phosphatase (PTPs), which play a significant role in maintaining...