Agonistic CD200R1 DNA Aptamers Are Potent Immunosuppressants That Prolong Allogeneic Skin Graft Survival

• Main Authors: Aaron Prodeus (Author), Marzena Cydzik (Author), Aws Abdul-Wahid (Author), Eric Huang (Author), Ismat Khatri (Author), Reginald Gorczynski (Author), Jean Gariépy (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CD200R1 expressed on the surface of myeloid and lymphoid cells delivers immune inhibitory signals to modulate inflammation when engaged with its ligand CD200. Signalling through CD200/CD200R1 has been implicated in a number of immune-related diseases including allergy, infection, cancer and transpla...