Development of Novel ROCK Inhibitors via 3D-QSAR and Molecular Docking Studies: A Framework for Multi-Target Drug Design

• Main Authors: Milan Beljkas (Author), Milos Petkovic (Author), Ana Vuletic (Author), Ana Djuric (Author), Juan Francisco Santibanez (Author), Tatjana Srdic-Rajic (Author), Katarina Nikolic (Author), Slavica Oljacic (Author)
• Format: Book
• Published: MDPI AG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<b>Background/Objectives:</b> Alterations in the actin cytoskeleton correlates to tumor progression and affect critical cellular processes such as adhesion, migration and invasion. Rho-associated coiled-coil-containing protein kinases (ROCK1 and ROCK2), important regulators of the actin...