Nicotinamide Phosphoribosyltransferase‐elevated NAD+ biosynthesis prevents muscle disuse atrophy by reversing mitochondrial dysfunction

• 主要な著者: Yao Zhang (著者), Yingming Wang (著者), Shuai Lu (著者), Rui Zhong (著者), Zhilin Liu (著者), Qichun Zhao (著者), Chongyang Wang (著者)
• フォーマット: 図書
• 出版事項: Wiley, 2023-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract Background It is well known that muscle disuse atrophy is associated with mitochondrial dysfunction, which is implicated in reduced nicotinamide adenine dinucleotide (NAD+) levels. Nicotinamide phosphoribosyltransferase (NAMPT), a rate‐limiting enzyme in NAD+ biosynthesis, may serve as a no...