Nicotinamide Phosphoribosyltransferase‐elevated NAD+ biosynthesis prevents muscle disuse atrophy by reversing mitochondrial dysfunction

• Main Authors: Yao Zhang (Author), Yingming Wang (Author), Shuai Lu (Author), Rui Zhong (Author), Zhilin Liu (Author), Qichun Zhao (Author), Chongyang Wang (Author)
• Format: Book
• Published: Wiley, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background It is well known that muscle disuse atrophy is associated with mitochondrial dysfunction, which is implicated in reduced nicotinamide adenine dinucleotide (NAD+) levels. Nicotinamide phosphoribosyltransferase (NAMPT), a rate‐limiting enzyme in NAD+ biosynthesis, may serve as a no...