Association of the gene polymorphisms IFN-gamma +874, IL-13 -1055 and IL-4 -590 with patterns of reinfection with Schistosoma mansoni.

• Main Authors: Michael R Gatlin (Author), Carla L Black (Author), Pauline N Mwinzi (Author), W Evan Secor (Author), Diana M Karanja (Author), Daniel G Colley (Author)
• Format: Bog
• Udgivet: Public Library of Science (PLoS), 2009-01-01T00:00:00Z.
• Fag: article
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The immunologic findings that most consistently correlate with resistance in human schistosomiasis are high levels of IgE and low levels of IgG4. We have genotyped gene and promoter polymorphisms of cytokines associated with regulation of these isotypes in a cohort of men occupationally exposed to S...