Retinal ganglion cell-specific genetic regulation in primary open-angle glaucoma

• Main Authors: Maciej Daniszewski (Author), Anne Senabouth (Author), Helena H. Liang (Author), Xikun Han (Author), Grace E. Lidgerwood (Author), Damián Hernández (Author), Priyadharshini Sivakumaran (Author), Jordan E. Clarke (Author), Shiang Y. Lim (Author), Jarmon G. Lees (Author), Louise Rooney (Author), Lerna Gulluyan (Author), Emmanuelle Souzeau (Author), Stuart L. Graham (Author), Chia-Ling Chan (Author), Uyen Nguyen (Author), Nona Farbehi (Author), Vikkitharan Gnanasambandapillai (Author), Rachael A. McCloy (Author), Linda Clarke (Author), Lisa S. Kearns (Author), David A. Mackey (Author), Jamie E. Craig (Author), Stuart MacGregor (Author), Joseph E. Powell (Author), Alice Pébay (Author), Alex W. Hewitt (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: To assess the transcriptomic profile of disease-specific cell populations, fibroblasts from patients with primary open-angle glaucoma (POAG) were reprogrammed into induced pluripotent stem cells (iPSCs) before being differentiated into retinal organoids and compared with those from healthy...